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Publication

Prof. Toshifumi INADA
Yoshitaka MATSUO
Toru SUZUKI

Toru SUZUKI

Original article

Narita, M.#, Denk, T.#, Matsuo, Y., Sugiyama, T., Kikuguchi, C., Ito, S., Sato, N., Suzuki, T., Hashimoto, S., Machová, I., Tesina, P., Beckmann, R., Inada, T.* (#Equal contribution)
A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation
Nat Commun.
doi:10.1038/s41467-022-34097-9
(2022)

Suzuki, T.*, Hoshina, M., Nishijima, S., Hoshina, N., Kikuguchi, C., Tomohiro, T., Fukao, A., Fujiwara, T., Yamamoto, T.*
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
RNA Biol. 
doi:10.1080/15476286.2021.2021676
(2022)

Suzuki, T., Adachi, S., Kikuguchi, C., Shibata, S., Nishijima, S., Kawamoto, Y., Iizuka, Y., Koseki, H., Okano, H., Natsume, T., Yamamoto.*
Regulation of fetal genes by transitions among RNA-binding proteins during liver development.
Int J Mol Sci.  
doi:10.3390/ijms21239319
(2020)

Ito-Kureha, T., Miyao, T., Nishijima, S., Suzuki, T., Kozumi, S-I., Villar-Brioness, A., Takahashi, A., Akiyama, N., Morita, M., Nagura, I., Ishikawa, H., Ichijo, H., Akiyama, T., Yamamoto, T.*
The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression.
Nat Commun. 
doi:10.1038/s41467-020-19975-4
(2020)

Mostafa, D., Yanagiya, A., Georgiadou, E., Wu, Y., Stylianides, T., Rutter, GA., Suzuki, T., Yamamoto, T.*
Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation.
Commun Biol. 
doi:10.1038/s42003-020-01201-y
(2020)

Otsuka, H., Fukao, A., Tomohiro, T., Adachi, S., Suzuki, T., Takahashi, A., Funakami, Y., Natsume, T., Yamamoto, T., Duncan, KE., Fujiwara, T.*
ARE-binding protein ZFP36L1 interacts with CNOT1 to directly repress translation via a deadenylation-independent mechanism.
Biochimie. 
doi:10.1016/j.biochi.2020.04.010
(2020)

Takahashi, A., Suzuki, T., Soeda, S., Takaoka, S., Kobori, S., Yamaguchi, T., Mohamed, H., Yanagiya, A., Abe, T., Shigeta, M., Furuta, Y., Kuba. K., Yamamoto, T.*
The CCR4-NOT complex maintains liver homeostasis through mRNA deadenylation.
Life Sci Alliance. 
doi:10.26508/lsa.201900494
(2020)

Mostafa, D., Takahashi, A., Yanagiya, A., Yamaguchi, T., Abe, T., Kureha, T., Kuba, K., Kanegae, Y., Furuta, Y., Yamamoto, T., Suzuki, T.*
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability.
RNA Biol. 
doi:10.1080/15476286.2019.1709747
(2020)

Suzuki, T., Kikuguchi, C., Nishijima, S., Yamamoto, T.*
Insufficient liver maturation affects murine early postnatal hair cycle.
Biochem Biophys Res Commun. 
doi:10.1016/j.bbrc.2019.10.099
(2020)

Takahashi, A., Takaoka, S., Kobori, S., Yamaguchi, T., Ferwati, S., Kuba, K., Yamamoto, T., Suzuki, T.*
The CCR4-NOT deadenylase complex maintains adipocyte identity.
Int J Mol Sci. 
doi:10.3390/ijms20215274
(2019)

Suzuki, T., Kikuguchi, C., Nishijima, S., Nagashima, T., Takahashi, A., Okada, M., Yamamoto, T.*
Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes.
Development 
doi:10.1242/dev.168146
(2019)

Li, X., Morita, M., Kikuguchi, C., Takahashi, A., Suzuki, T., Yamamoto, T.*
Adipocyte-specific disruption of mouse Cnot3 causes lipodystrophy.
FEBS Lett. 
doi:10.1002/1873-3468.12550
(2017)

Zukeran, A., Takahashi, A., Takaoka, A., Mohamed, HMA., Suzuki, T., Ikematsu, S., Yamamoto, T.*
The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells.
Biochem Biophys Res Commun. 
doi:10.1016/j.bbrc.2016.03.119
(2016)

Suzuki, T., Kikuguchi, C., Sharma, S., Sasaki, T., Tokumasu, M., Adachi, S., Natsume, T., Kanegae, Y., Yamamoto, T.*
CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins.
Sci Rep. 
doi:10.1038/srep14779
(2015)

Takahashi, A., Adachi, S., Morita, M., Tokumasu, M., Natsume, T., Suzuki, T., Yamamoto, T.*
Post-transcriptional stabilization of Ucp1 mRNA protects mice from diet-induced obesity.
Cell Rep. 
doi:10.1016/j.celrep.2015.11.056
(2015)

Bai, Y., Tashiro, S., Nagatoishi, S., Suzuki, T., Yan, D., Tsumoto, K., Bartlam, M., Yamamoto, T.*
Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach.
Protein Cell 
doi:10.1007/s13238-015-0225-6
(2015)

Suzuki, T., Tsuzuki, J., Hayashi, A., Shiomi, Y., Iwanari, H., Mochizuki, Y., Hamakubo, T., Kodama, T., Nishitani, H., Masai, H., Yamamoto, T.*
Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.
J Biol Chem. 
doi:10.1074/jbc.M112.353805
(2012)

Takahashi, A., Morita, M., Yokoyama, K., Suzuki, T., Yamamoto, T.*
Tob2 inhibits PPARg2 expression by sequestering Smads and C/EBPa during adipocyte differentiation.
Mol Cell Biol. 
doi:10.1016/j.molcel.2022.08.018
(2012)

Takahashi, A., Kikuguchi, C., Morita, M., Shimodaira, T., Tokai-Nishizumi, N., Yokoyama, K., Ohsugi, M., Suzuki, T., Yamamoto, T.*
Involvement of CNOT3 in mitotic progression through inhibition of MAD1 expression.
Biochem Biophys Res Commun. 
doi:10.1016/j.bbrc.2012.02.007
(2012)

Ito, K., Takahashi, A., Morita, M., Suzuki, T., Yamamoto, T.*
The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability.
Protein Cell. 
doi:10.1007/s13238-011-1092-4
(2011) 

Morita, M., Oike, Y., Nagashima, T., Kadomatsu, T., Tabata, M., Suzuki, T., Nakamura, T., Yoshida, N., Okada, M., Yamamoto, T.*
Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice.
EMBO J. 
doi:10.1038/emboj.2011.320
(2011)

Chen, C., Ito, K., Takahashi, A., Wang, G., Suzuki, T., Nakazawa, T., Yamamoto, T., Yokoyama, K.*
Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development.
Biochem Biophys Res Commun. 
doi:10.1016/j.bbrc.2011.06.148
(2011)

Suzuki, T., Kim, M., Kozuka-Hata, H., Watanabe, M., Oyama, M., Tsumoto, K., Yamamoto, T.*
Monoubiquitination of Tob/BTG family proteins competes with degradation-targeting polyubiquitination.
Biochem Biophys Res Commun. 
doi:10.1016/j.bbrc.2011.04.107
(2011)

Ito, K., Inoue, T., Yokoyama, K., Morita, M., Suzuki, T., Yamamoto, T.*
CNOT2-depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death.
Genes Cells. 
doi:10.1111/j.1365-2443.2011.01492.x
(2011)

Watanabe, M., Suzuki, T., Kim, M., Abe, Y., Yoshida, Y., Sugano, S., Yamamoto, T.*
Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
FEBS Lett. 
doi:10.1016/j.febslet.2010.11.049
(2010)

Wang, H., Morita, M., Yang, X., Suzuki, T., Yang, W., Wang, J., Ito, K., Wang, Q., Zhao, C., Bartlam, M., Yamamoto, T., Rao, Z.*
Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.
EMBO J. 
doi:10.1038/emboj.2010.152
(2010)

Horiuchi, M., Takeuchi, K., Noda, N., Muroya, N., Suzuki, T., Nakamura, T., Kawamura-Tsuzuku, J., Takahasi, K., Yamamoto, T., Inagaki F.*
Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
J Biol Chem. 
doi:10.1074/jbc.M809250200
(2009)

Yoneda, M., Suzuki, T., Nakamura, T., Ajima, R., Yoshida, Y., Kakuta, S., Sudo, K., Iwakura, Y., Shibutani, M., Mitsumori, K., Yokota, J., Yamamoto, T.*
Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
Cancer Sci. 
doi:10.1111/j.1349-7006.2008.01030.x
(2009)

Suzuki, T., Tsuzuku, J., Kawakami, K., Miyasaka, T., Yamamoto, T.*
Proteasome-mediated degradation of Tob is pivotal for triggering UV-induced apoptosis.
Oncogene 
doi:10.1038/onc.2008.387
(2009)

Yang, X., Morita, M., Wang, H., Suzuki, T., Yang, W., Luo, Y., Zhao, C., Yu, Y., Bartlam, M., Yamamoto, T., Rao, Z.*
Crystal structures of human BTG2 and mouse TIS21 involved in suppression of CAF1 deadenylase activity.
Nucleic Acids Res. 
doi:10.1093/nar/gkn825
(2008)

Miyasaka T, Morita M, Ito K, Suzuki T, Fukuda H, Takeda S, Inoue J, Semba K, Yamamoto T.*
Interaction of anti-proliferative protein Tob with the CCR4-NOT deadenylase complex.
Cancer Sci. 
doi:10.1111/j.1349-7006.2008.00746.x
(2008)

Morita, M., Suzuki, T., Nakamura, T., Yokoyama, K., Miyasaka, T., Yamamoto, T.*
Depletion of mammalian CCR4b deadenylase triggers elevation of the p27kip1 mRNA level and impairs cell growth.
Mol Cell Biol. 
doi:10.1128/MBC.02304-06
(2007)

Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, K., Yamamoto, T., Konno, H., Kitagawa, M.*
Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination.
Cancer Res.  
doi:10.1158/0008-5472.CAN-06-1603
(2006)

Ito, Y., Suzuki, T., Yoshida, H., Tomoda, C., Uruno, T., Takamura, Y., Miya, A., Kobayashi, K., Matsuzuka, F., Kuma, K., Yamamoto, T., Miyauchi, A.*
Phosphorylation and inactivation of Tob contributes to the progression of papillary carcinoma of the thyroid.
Cancer lett. 
doi:10.1016/j.canlet.2004.08.017
(2005)

Okochi, K., Suzuki, T., Inoue, J., Matsuda, S., Yamamoto, T.*
Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control.
Genes Cells. 
doi:10.1111/j.1365-2443.2005.00826.x
(2005)

Kawamura-Tsuzuku, J., Suzuki, T., Yoshida, Y., Yamamoto, T.*
Nuclear localization of Tob is important for regulation of its antiproliferative activity.
Oncogene 
doi:10.1038/sj.onc.1207890
(2004)

Nakamura, T., Yao, R., Ogawa, T., Suzuki, T., Ito, C., Tsunekawa, N., Inoue, K., Ajima, R., Miyasaka, T., Yoshida, Y., Ogura, A., Toshimori, K., Noce, T., Yamamoto, T., Noda, T.*
Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta.
Nat Genet. 
doi:10.1038/ng1344
(2004)

Iwanaga, K., Sueoka, N., Sato, A., Sakuragi, K., Sakao, Y., Tominaga, M., Suzuki, T., Yoshida, Y., Tsuzuku, J., Yamamoto, T., Hayashi, S., Nagasawa, K., Sueoka, E.*
Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer.
Cancer lett. 
doi:10.1016/j.canlet.2003.08.019
(2003)

Yoshida, Y., Nakamura, T., Komoda, M., Satoh, H., Suzuki, T., Tsuzuku, J., Miyasaka, T., Yoshida, E., Umemori, H., Kunisaki, RK., Tani, K., Ishii, S., Mori, S., Suganuma, M., Noda, T., Yamamoto, T.*
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
Genes Dev. 
doi:10.1101/gad.1088003
(2003)

Suzuki, T., K-Tsuzuku, J., Ajima, R., Nakamura, T., Yoshida, Y., Yamamoto, T.*
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation.
Genes Dev. 
doi:10.1101/gad.962802
(2002)

Suzuki, T., Matsuda, S., Tsuzuku, JK., Yoshida, Y., Yamamoto, T.*
A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob.
Genes Cells. 
doi:10.1046/j.1365-2443.2001.00406.x
(2001)

Review

Akiyama, T., Suzuki, T., Yamamoto, T.*
RNA decay machinery safeguards immune cell development and immunological responses.
Trends Immunol. 
doi:10.1016/j.it.2021.03.008
(2021)

hirai, Y., Suzuki, T., Morita, M., Takahashi, A., Yamamoto, T.*
Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena.
Front Genet
. 
doi:10.3389/fgene.2014.00286
(2014)

東京大学医科学研究所基礎医科学部門

RNA制御学分野

〒108-8639 東京都港区白金台4丁目6−1

Division of RNA and Gene Regulation

The Institute of Medical Science, The University of Tokyo

4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

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